The world’s energy sector is undergoing a profound transition. This transition is driven by the need to expand access to clean energy in support of socio-economic development, especially in emerging economies, while at the same time limiting the impacts of climate change, pollution and other unfolding global environmental crises. Fundamentally this transition requires a shift from the use of polluting energy sources towards the use of sustainable alternatives. The ongoing Covid-19 pandemic also reminds us of the importance of resilience in the energy system and is a profound motivation for countries to ‘build back better’. There are many pathways to achieving this transition and each country will pursue its own route, taking into account its own endowment of natural resources as well as other local and regional factors. The UN’s 2030 agenda, distilled in the sustainable development goals, has become an indispensable tool for decision-makers concerned with navigating these difficult decisions. This report explores the potential for nuclear energy as part of the energy portfolio and shows how the utilisation of local or regional uranium resources can provide a platform for sustainable development. It explores potential entry pathways in the context of local and regional factors, including the utilization of domestic uranium resources, which could facilitate nuclear energy and economic development by applying the United Nations Framework Classification for Resources (UNFC) and United Nations Resource Management System (UNRMS).